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Learn All About JNK Antibody

JNK1 can also be involved with UV (ultra violet) radiation-induced apoptosis which is believed to be linked to the Cytochrome C-mediated cell death. JNK1 (or MAPK8) is serine threonine-kinase which is an essential regulator of cell Apoptosis. When there is no NFkB stimulation, constant activation of JNK1 causes TNF-a-induced cell death. 

But, JNK1 may also function as an inhibitor of apoptosis. In this case, JNK1 works with WOX1 to stop the process of apoptosis. In addition, JNK1 phosphorylates Bcl-2 to facilitate autophagy induced by starvation, and is also able to activate SIRT1 by phosphorylation under conditions of the oxidative stress. You can buy Anti-JNK1/MAPK8 Antibody PA1892 online.

The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. 

Like the other MAPKs their signaling unit is composed of an MAPKKK generally MEKK1-MEKK4, or some of the mixed lineage (MLKs) which are phosphorylated to activate the MKK4/7. When activated, MKKs phosphorylate and activate the kinase of SAPK/JNK. Stress signals are transmitted to this cascade via small GTPases belonging to the Rho family. 

The two Rac1 and cdc42 are involved in activation of MEKKs as well as MLKs. Additionally, MKK4/7 may be activated through a GTPase-independent mechanism by stimulating the germinal center-kinase (GCK) Family member. Three SAPK/JNK genes are present, each of them undergoes different splicing, which results in a variety of forms.